DegronMD

Uniprot ID: Q4G0N8

Source protein: Sodium/hydrogen exchanger 10

Source gene: SLC9C1

Class: DEG_APCC_DBOX_1

Location: 1167:1175

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9765

ASA_SCORE: 103.6778

COIL: 0.54

CONS_SCORE: 0.2835

DSS_SCORE: 0.6641

HELIX: 0.3926

FCONS_SCORE: 1.0836

RIG_SCORE: 0.7815

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1171I	TCGA-19-5956	GBM	TCGA	PRINLRKVR	DEG_APCC_DBOX_1	0.7174
p.G1158W	TCGA-64-1677	LUAD	TCGA	PRINLRKVR	DEG_APCC_DBOX_1	0.0833
p.L1171Q	TCGA-CN-5360	HNSC	TCGA	PRINLRKVR	DEG_APCC_DBOX_1	0.7765
p.E1177G	ACH-002396	Bone Cancer	CCLE	PRINLRKVR	DEG_APCC_DBOX_1	0.2778
p.E1177G	Sarc9371	bone	COSMIC	PRINLRKVR	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G0N8	Sodium/hydrogen exchanger 10	DEG_APCC_DBOX_1	1167:1175	PRINLRKVR	APC,CDC20,FZR1	0.9765	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons