DegronMD - Q4G0P3(HYDIN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V2566L	TCGA-05-4396	LUAD	TCGA	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.1944
p.V2566L	DO23838	LUAD	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.1944
p.G2565V	TCGA-AA-A022	COAD	TCGA	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.1667
p.G2565V	DO10647	COAD	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.1667
p.K2582E	TCGA-B2-4099	KIRC	TCGA	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation substituting flanking lysine	0.3056
p.K2582E	DO18988	KIRC	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation substituting flanking lysine	0.3056
p.E2561K	TCGA-BF-AAP1	SKCM	TCGA	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.0556
p.E2561K	DO229479	SKCA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.0556
p.E2561K	DO219464	SKCM	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.0556
p.E2586K	TCGA-D3-A51G	SKCM	TCGA	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.0833
p.E2586K	DO47700	SKCM	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.0833
p.L2569I	TCGA-FS-A1ZJ	SKCM	TCGA	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.2778
p.L2569I	DO37956	SKCM	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.2778
p.F2576S	TCGA-IB-7651	PAAD	TCGA	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation altering degron motif	0.6871
p.F2576S	DO46657	PAAD	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation altering degron motif	0.6871
p.D2570N	DO48407	BLCA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.3056
p.D2570N	DO48402	BLCA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.3056
p.D2570N	DO48444	BLCA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.3056
p.V2566I	DO227774	COCA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.1944
p.V2566I	DO233708	GACA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.1944
p.F2568V	DO233840	GACA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.25
p.Q2583K	DO229036	LICA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.1667
p.G2565S	DO220851	MELA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.1667
p.G2578D	DO220852	MELA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	2571:2577	Mutation rewiring degron network	0.3056

Kaplan plot for HYDIN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HYDIN

UniProt ID: Q4G0P3

Entrez ID: 54768

Protein name: Hydrocephalus-inducing protein homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HYDIN in