DegronMD

Uniprot ID: Q4G0P3

Source protein: Hydrocephalus-inducing protein homolog

Source gene: HYDIN

Class: DEG_SCF_FBW7_2

Location: 2571:2577

E3 ligase: FBXW7

DEGRON score: 0.5519

ASA_SCORE: 59.3143

COIL: 0.6504

CONS_SCORE: 0.3653

DSS_SCORE: 0.428

HELIX: 0.1

FCONS_SCORE: 1.0397

RIG_SCORE: 0.7925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2566L	TCGA-05-4396	LUAD	TCGA	IQTPDFE	DEG_SCF_FBW7_2	0.1944
p.V2566L	DO23838	LUAD	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.1944
p.G2565V	TCGA-AA-A022	COAD	TCGA	IQTPDFE	DEG_SCF_FBW7_2	0.1667
p.G2565V	DO10647	COAD	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.1667
p.K2582E	TCGA-B2-4099	KIRC	TCGA	IQTPDFE	DEG_SCF_FBW7_2	0.3056
p.K2582E	DO18988	KIRC	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.3056
p.E2561K	TCGA-BF-AAP1	SKCM	TCGA	IQTPDFE	DEG_SCF_FBW7_2	0.0556
p.E2561K	DO229479	SKCA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.0556
p.E2561K	DO219464	SKCM	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.0556
p.E2586K	TCGA-D3-A51G	SKCM	TCGA	IQTPDFE	DEG_SCF_FBW7_2	0.0833
p.E2586K	DO47700	SKCM	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.0833
p.L2569I	TCGA-FS-A1ZJ	SKCM	TCGA	IQTPDFE	DEG_SCF_FBW7_2	0.2778
p.L2569I	DO37956	SKCM	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.2778
p.F2576S	TCGA-IB-7651	PAAD	TCGA	IQTPDFE	DEG_SCF_FBW7_2	0.6871
p.F2576S	DO46657	PAAD	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.6871
p.D2570N	DO48407	BLCA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.3056
p.D2570N	DO48402	BLCA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.3056
p.D2570N	DO48444	BLCA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.3056
p.V2566I	DO227774	COCA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.1944
p.V2566I	DO233708	GACA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.1944
p.F2568V	DO233840	GACA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.25
p.Q2583K	DO229036	LICA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.1667
p.G2565S	DO220851	MELA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.1667
p.G2578D	DO220852	MELA	ICGC	IQTPDFE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G0P3	Hydrocephalus-inducing protein homolog	DEG_SCF_FBW7_2	2571:2577	IQTPDFE	FBXW7	0.5519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons