DegronMD - Q4G0X9(CCDC40)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G239E	TCGA-DS-A1OB	CESC	TCGA	LPVFQD	LIG_APCC_ABBA_1	241:246	Mutation rewiring degron network	0.2778
p.G239E	DO6323	CESC	ICGC	LPVFQD	LIG_APCC_ABBA_1	241:246	Mutation rewiring degron network	0.2778
p.A234V	TCGA-W3-AA1R	SKCM	TCGA	LPVFQD	LIG_APCC_ABBA_1	241:246	Mutation rewiring degron network	0.1389
p.A234V	DO51275	SKCM	ICGC	LPVFQD	LIG_APCC_ABBA_1	241:246	Mutation rewiring degron network	0.1389
p.F244I	TCGA-Z2-A8RT	SKCM	TCGA	LPVFQD	LIG_APCC_ABBA_1	241:246	Mutation altering degron motif	0.7415
p.F244I	DO51301	SKCM	ICGC	LPVFQD	LIG_APCC_ABBA_1	241:246	Mutation altering degron motif	0.7415
p.E255K	DO222843	MELA	ICGC	LPVFQD	LIG_APCC_ABBA_1	241:246	Mutation rewiring degron network	0.0833
p.H235P	DO229253	THCA	ICGC	LPVFQD	LIG_APCC_ABBA_1	241:246	Mutation rewiring degron network	0.1667
p.D233N	SIDM00941	Kidney Carcinoma	GDSC	LPVFQD	LIG_APCC_ABBA_1	241:246	Mutation rewiring degron network	0.1111
p.D233N	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LPVFQD	LIG_APCC_ABBA_1	241:246	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons