DegronMD

Uniprot ID: Q4G0X9

Source protein: Coiled-coil domain-containing protein 40

Source gene: CCDC40

Class: LIG_APCC_ABBA_1

Location: 241:246

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.796

ASA_SCORE: 85.8333

COIL: 0.6703

CONS_SCORE: 0.2897

DSS_SCORE: 0.8399

HELIX: 0.2978

FCONS_SCORE: 1.0915

RIG_SCORE: 0.7372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G239E	TCGA-DS-A1OB	CESC	TCGA	LPVFQD	LIG_APCC_ABBA_1	0.2778
p.G239E	DO6323	CESC	ICGC	LPVFQD	LIG_APCC_ABBA_1	0.2778
p.A234V	TCGA-W3-AA1R	SKCM	TCGA	LPVFQD	LIG_APCC_ABBA_1	0.1389
p.A234V	DO51275	SKCM	ICGC	LPVFQD	LIG_APCC_ABBA_1	0.1389
p.F244I	TCGA-Z2-A8RT	SKCM	TCGA	LPVFQD	LIG_APCC_ABBA_1	0.7415
p.F244I	DO51301	SKCM	ICGC	LPVFQD	LIG_APCC_ABBA_1	0.7415
p.E255K	DO222843	MELA	ICGC	LPVFQD	LIG_APCC_ABBA_1	0.0833
p.H235P	DO229253	THCA	ICGC	LPVFQD	LIG_APCC_ABBA_1	0.1667
p.D233N	SIDM00941	Kidney Carcinoma	GDSC	LPVFQD	LIG_APCC_ABBA_1	0.1111
p.D233N	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LPVFQD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G0X9	Coiled-coil domain-containing protein 40	LIG_APCC_ABBA_1	241:246	LPVFQD	APC,CDC20,FZR1	0.796	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons