DegronMD - Q4KMZ1(IQCC)

IQCC

UniProt ID: Q4KMZ1

Entrez ID: 55721

Protein name: IQ domain-containing protein C

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G350W	TCGA-A5-A0G2	UCEC	TCGA	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.2222
p.G350W	DO41235	UCEC	ICGC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.2222
p.R330S	TCGA-AG-A011	READ	TCGA	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.1111
p.V331F	TCGA-AG-A011	READ	TCGA	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.1389
p.Q345E	TCGA-E9-A1RD	BRCA	TCGA	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation altering degron motif	0.6744
p.Q345E	DO5354	BRCA	ICGC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation altering degron motif	0.6744
p.S333T	DO23148	LINC	ICGC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.1944
p.K352T	DO23436	LINC	ICGC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation substituting flanking lysine	0.2778
p.P338S	DO222363	MELA	ICGC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation altering degron motif	0.6752
p.N347K	SIDM01112	Osteosarcoma	GDSC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.3056
p.N347K	SJSA-1	bone	COSMIC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.3056
p.G339R	SIDM00333	Endometrial Carcinoma	GDSC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation altering degron motif	0.7568
p.G339R	MFE-319	endometrium	COSMIC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation altering degron motif	0.7568
p.P334R	SIDM00522	Small Cell Lung Carcinoma	GDSC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.2222
p.P334R	SIDM01765	Osteosarcoma	GDSC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.2222
p.P334R	DMS-273	lung	COSMIC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.2222
p.S349P	ACH-000423	Skin Cancer	CCLE	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.25
p.S349P	SK-MEL-3	skin	COSMIC	SRTQLSALY	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.25

Kaplan plot for IQCC in

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*NOTE: the Kaplan plots were collected from OncoLnc