DegronMD

Uniprot ID: Q4KMZ1

Source protein: IQ domain-containing protein C

Source gene: IQCC

Class: DEG_APCC_DBOX_1

Location: 338:346

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9548

ASA_SCORE: 93.0667

COIL: 0.6728

CONS_SCORE: 0.3999

DSS_SCORE: 0.5798

HELIX: 0.2872

FCONS_SCORE: 1.1521

RIG_SCORE: 0.7014

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G350W	TCGA-A5-A0G2	UCEC	TCGA	SRTQLSALY	DEG_APCC_DBOX_1	0.2222
p.G350W	DO41235	UCEC	ICGC	SRTQLSALY	DEG_APCC_DBOX_1	0.2222
p.R330S	TCGA-AG-A011	READ	TCGA	SRTQLSALY	DEG_APCC_DBOX_1	0.1111
p.V331F	TCGA-AG-A011	READ	TCGA	SRTQLSALY	DEG_APCC_DBOX_1	0.1389
p.Q345E	TCGA-E9-A1RD	BRCA	TCGA	SRTQLSALY	DEG_APCC_DBOX_1	0.6744
p.Q345E	DO5354	BRCA	ICGC	SRTQLSALY	DEG_APCC_DBOX_1	0.6744
p.S333T	DO23148	LINC	ICGC	SRTQLSALY	DEG_APCC_DBOX_1	0.1944
p.K352T	DO23436	LINC	ICGC	SRTQLSALY	DEG_APCC_DBOX_1	0.2778
p.P338S	DO222363	MELA	ICGC	SRTQLSALY	DEG_APCC_DBOX_1	0.6752
p.N347K	SIDM01112	Osteosarcoma	GDSC	SRTQLSALY	DEG_APCC_DBOX_1	0.3056
p.N347K	SJSA-1	bone	COSMIC	SRTQLSALY	DEG_APCC_DBOX_1	0.3056
p.G339R	SIDM00333	Endometrial Carcinoma	GDSC	SRTQLSALY	DEG_APCC_DBOX_1	0.7568
p.G339R	MFE-319	endometrium	COSMIC	SRTQLSALY	DEG_APCC_DBOX_1	0.7568
p.P334R	SIDM00522	Small Cell Lung Carcinoma	GDSC	SRTQLSALY	DEG_APCC_DBOX_1	0.2222
p.P334R	SIDM01765	Osteosarcoma	GDSC	SRTQLSALY	DEG_APCC_DBOX_1	0.2222
p.P334R	DMS-273	lung	COSMIC	SRTQLSALY	DEG_APCC_DBOX_1	0.2222
p.S349P	ACH-000423	Skin Cancer	CCLE	SRTQLSALY	DEG_APCC_DBOX_1	0.25
p.S349P	SK-MEL-3	skin	COSMIC	SRTQLSALY	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KMZ1	IQ domain-containing protein C	DEG_APCC_DBOX_1	338:346	SRTQLSALY	APC,CDC20,FZR1	0.9548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons