DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRTQLSALY
Uniprot ID:
Q4KMZ1
Source protein:
IQ domain-containing protein C
Source gene:
IQCC
Class:
DEG_APCC_DBOX_1
Location:
338:346
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9548
ASA_SCORE:
93.0667
COIL:
0.6728
CONS_SCORE:
0.3999
DSS_SCORE:
0.5798
HELIX:
0.2872
FCONS_SCORE:
1.1521
RIG_SCORE:
0.7014
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G339R
SIDM00333
Endometrial Carcinoma
GDSC
SRTQLSALY
DEG_APCC_DBOX_1
0.7568
p.G339R
MFE-319
endometrium
COSMIC
SRTQLSALY
DEG_APCC_DBOX_1
0.7568
p.P338S
DO222363
MELA
ICGC
SRTQLSALY
DEG_APCC_DBOX_1
0.6752
p.Q345E
TCGA-E9-A1RD
BRCA
TCGA
SRTQLSALY
DEG_APCC_DBOX_1
0.6744
p.Q345E
DO5354
BRCA
ICGC
SRTQLSALY
DEG_APCC_DBOX_1
0.6744
p.N347K
SIDM01112
Osteosarcoma
GDSC
SRTQLSALY
DEG_APCC_DBOX_1
0.3056
p.N347K
SJSA-1
bone
COSMIC
SRTQLSALY
DEG_APCC_DBOX_1
0.3056
p.K352T
DO23436
LINC
ICGC
SRTQLSALY
DEG_APCC_DBOX_1
0.2778
p.S349P
ACH-000423
Skin Cancer
CCLE
SRTQLSALY
DEG_APCC_DBOX_1
0.25
p.S349P
SK-MEL-3
skin
COSMIC
SRTQLSALY
DEG_APCC_DBOX_1
0.25
p.G350W
TCGA-A5-A0G2
UCEC
TCGA
SRTQLSALY
DEG_APCC_DBOX_1
0.2222
p.G350W
DO41235
UCEC
ICGC
SRTQLSALY
DEG_APCC_DBOX_1
0.2222
p.P334R
SIDM00522
Small Cell Lung Carcinoma
GDSC
SRTQLSALY
DEG_APCC_DBOX_1
0.2222
p.P334R
SIDM01765
Osteosarcoma
GDSC
SRTQLSALY
DEG_APCC_DBOX_1
0.2222
p.P334R
DMS-273
lung
COSMIC
SRTQLSALY
DEG_APCC_DBOX_1
0.2222
p.S333T
DO23148
LINC
ICGC
SRTQLSALY
DEG_APCC_DBOX_1
0.1944
p.V331F
TCGA-AG-A011
READ
TCGA
SRTQLSALY
DEG_APCC_DBOX_1
0.1389
p.R330S
TCGA-AG-A011
READ
TCGA
SRTQLSALY
DEG_APCC_DBOX_1
0.1111
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Drug responses associated with IQCC mutations
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Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of SRTQLSALY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q4KMZ1
IQ domain-containing protein C
DEG_APCC_DBOX_1
338:346
SRTQLSALY
APC,CDC20,FZR1
0.9548
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