DegronMD - Q4LDE5(SVEP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I2619M	TCGA-44-7669	LUAD	TCGA	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation altering degron motif	0.6507
p.I2619M	DO25262	LUAD	ICGC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation altering degron motif	0.6507
p.D2623N	TCGA-97-A4M7	LUAD	TCGA	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.25
p.D2623N	DO45386	LUAD	ICGC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.25
p.L2627R	TCGA-AJ-A3EL	UCEC	TCGA	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.1389
p.L2627R	DO41542	UCEC	ICGC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.1389
p.D2620N	TCGA-D3-A3MV	SKCM	TCGA	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation altering degron motif	0.6932
p.D2620N	DO37727	SKCM	ICGC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation altering degron motif	0.6932
p.D2629N	DO222908	MELA	ICGC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.0833
p.T2607A	SIDM00585	Hepatocellular Carcinoma	GDSC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.1111
p.T2607A	SIDM00045	Gastric Carcinoma	GDSC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.1111
p.T2607A	HuH-7	liver	COSMIC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.1111
p.T2607A	HSC-39	stomach	COSMIC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.1111
p.E2619K	ACH-001550	Skin Cancer	CCLE	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation altering degron motif	0.7022
p.T2610A	HSC-39	stomach	COSMIC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.1944
p.T2610A	HuH-7	liver	COSMIC	LPPHID	LIG_APCC_ABBA_1	2615:2620	Mutation rewiring degron network	0.1944

Kaplan plot for SVEP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SVEP1

UniProt ID: Q4LDE5

Entrez ID: 79987

Protein name: Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SVEP1 in