DegronMD

Uniprot ID: Q4LDE5

Source protein: Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Source gene: SVEP1

Class: LIG_APCC_ABBA_1

Location: 2615:2620

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8505

ASA_SCORE: 66.5833

COIL: 0.7693

CONS_SCORE: 0.231

DSS_SCORE: 0.2141

HELIX: 0.0302

FCONS_SCORE: 0.7974

RIG_SCORE: 0.7508

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I2619M	TCGA-44-7669	LUAD	TCGA	LPPHID	LIG_APCC_ABBA_1	0.6507
p.I2619M	DO25262	LUAD	ICGC	LPPHID	LIG_APCC_ABBA_1	0.6507
p.D2623N	TCGA-97-A4M7	LUAD	TCGA	LPPHID	LIG_APCC_ABBA_1	0.25
p.D2623N	DO45386	LUAD	ICGC	LPPHID	LIG_APCC_ABBA_1	0.25
p.L2627R	TCGA-AJ-A3EL	UCEC	TCGA	LPPHID	LIG_APCC_ABBA_1	0.1389
p.L2627R	DO41542	UCEC	ICGC	LPPHID	LIG_APCC_ABBA_1	0.1389
p.D2620N	TCGA-D3-A3MV	SKCM	TCGA	LPPHID	LIG_APCC_ABBA_1	0.6932
p.D2620N	DO37727	SKCM	ICGC	LPPHID	LIG_APCC_ABBA_1	0.6932
p.D2629N	DO222908	MELA	ICGC	LPPHID	LIG_APCC_ABBA_1	0.0833
p.T2607A	SIDM00585	Hepatocellular Carcinoma	GDSC	LPPHID	LIG_APCC_ABBA_1	0.1111
p.T2607A	SIDM00045	Gastric Carcinoma	GDSC	LPPHID	LIG_APCC_ABBA_1	0.1111
p.T2607A	HuH-7	liver	COSMIC	LPPHID	LIG_APCC_ABBA_1	0.1111
p.T2607A	HSC-39	stomach	COSMIC	LPPHID	LIG_APCC_ABBA_1	0.1111
p.E2619K	ACH-001550	Skin Cancer	CCLE	LPPHID	LIG_APCC_ABBA_1	0.7022
p.T2610A	HSC-39	stomach	COSMIC	LPPHID	LIG_APCC_ABBA_1	0.1944
p.T2610A	HuH-7	liver	COSMIC	LPPHID	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4LDE5	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1	LIG_APCC_ABBA_1	2615:2620	LPPHID	APC,CDC20,FZR1	0.8505	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons