DegronMD - Q4V9L6(TMEM119)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P64L	TCGA-29-1691	OV	TCGA	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.3056
p.P64L	DO32133	OV	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.3056
p.T73I	TCGA-BA-6872	HNSC	TCGA	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0556
p.T73I	DO14236	HNSC	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0556
p.S50F	TCGA-D9-A1JW	SKCM	TCGA	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1667
p.S50F	DO37786	SKCM	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1667
p.S66L	TCGA-EE-A182	SKCM	TCGA	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.25
p.S66L	DO37814	SKCM	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.25
p.S66L	ACH-001568	Skin Cancer	CCLE	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.25
p.S50Y	TCGA-L9-A7SV	LUAD	TCGA	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1667
p.S50Y	DO49875	LUAD	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1667
p.S50Y	ACH-001839	Bile Duct Cancer	CCLE	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1667
p.I72T	DO229010	COCA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.I72T	DO229013	COCA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.I72T	DO229016	COCA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.I72T	DO229003	COCA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.I72T	DO229005	COCA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.I72T	DO234285	ESAD	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.I72T	DO229489	LAML	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.L62F	DO234285	ESAD	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation altering degron motif	0.587
p.L62F	DO231075	LUSC	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation altering degron motif	0.587
p.L62I	DO233634	GACA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation altering degron motif	0.6063
p.S51T	DO232849	NACA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1944
p.S47L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.S47L	SIDM00910	Neuroblastoma	GDSC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.S47L	CHP-212	autonomic ganglia	COSMIC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.S47L	NCI-H2172	lung	COSMIC	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.P56L	ACH-001282	Bone Cancer	CCLE	PPWTPALS	DEG_SCF_FBW7_1	56:63	Mutation altering degron motif	0.6471

Kaplan plot for TMEM119 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM119

UniProt ID: Q4V9L6

Entrez ID: 338773

Protein name: Transmembrane protein 119 (Osteoblast induction factor) (OBIF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM119 in