DegronMD

Uniprot ID: Q4V9L6

Source protein: Transmembrane protein 119

Source gene: TMEM119

Class: DEG_SCF_FBW7_1

Location: 56:63

E3 ligase: FBXW7

DEGRON score: 0.9297

ASA_SCORE: 74.825

COIL: 0.9335

CONS_SCORE: 0.6994

DSS_SCORE: 0.66

HELIX: 0.0176

FCONS_SCORE: 1.1809

RIG_SCORE: 0.6157

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P56L	ACH-001282	Bone Cancer	CCLE	PPWTPALS	DEG_SCF_FBW7_1	0.6471
p.L62I	DO233634	GACA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.6063
p.L62F	DO234285	ESAD	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.587
p.L62F	DO231075	LUSC	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.587
p.P64L	TCGA-29-1691	OV	TCGA	PPWTPALS	DEG_SCF_FBW7_1	0.3056
p.P64L	DO32133	OV	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.3056
p.S66L	TCGA-EE-A182	SKCM	TCGA	PPWTPALS	DEG_SCF_FBW7_1	0.25
p.S66L	DO37814	SKCM	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.25
p.S66L	ACH-001568	Skin Cancer	CCLE	PPWTPALS	DEG_SCF_FBW7_1	0.25
p.S51T	DO232849	NACA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.1944
p.S50F	TCGA-D9-A1JW	SKCM	TCGA	PPWTPALS	DEG_SCF_FBW7_1	0.1667
p.S50F	DO37786	SKCM	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.1667
p.S50Y	TCGA-L9-A7SV	LUAD	TCGA	PPWTPALS	DEG_SCF_FBW7_1	0.1667
p.S50Y	DO49875	LUAD	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.1667
p.S50Y	ACH-001839	Bile Duct Cancer	CCLE	PPWTPALS	DEG_SCF_FBW7_1	0.1667
p.I72T	DO229010	COCA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.0833
p.I72T	DO229013	COCA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.0833
p.I72T	DO229016	COCA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.0833
p.I72T	DO229003	COCA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.0833
p.I72T	DO229005	COCA	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.0833
p.I72T	DO234285	ESAD	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.0833
p.I72T	DO229489	LAML	ICGC	PPWTPALS	DEG_SCF_FBW7_1	0.0833
p.S47L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPWTPALS	DEG_SCF_FBW7_1	0.0833
p.S47L	SIDM00910	Neuroblastoma	GDSC	PPWTPALS	DEG_SCF_FBW7_1	0.0833
p.S47L	CHP-212	autonomic_ganglia	COSMIC	PPWTPALS	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4V9L6	Transmembrane protein 119	DEG_SCF_FBW7_1	56:63	PPWTPALS	FBXW7	0.9297	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons