DegronMD - Q4VC44(FLYWCH1)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G180R	DO7990	COAD	ICGC	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1667
p.R185H	DO227802	COCA	ICGC	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.3056
p.R184Q	DO28823	OV	ICGC	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.R184Q	SIDM01088	Endometrial Carcinoma	GDSC	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.R184Q	ACH-000965	Endometrial/Uterine Cancer	CCLE	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.S192G	DO229268	THCA	ICGC	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.6993
p.E197V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.25
p.E197V	SIDM00793	Burkitt's Lymphoma	GDSC	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.25
p.E197V	SIDM00621	Ewing's Sarcoma	GDSC	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.25
p.E197V	SIDM00314	Breast Carcinoma	GDSC	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.25
p.R184C	ACH-001516	Cervical Cancer	CCLE	QREKLPSLA	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons