DegronMD

Uniprot ID: Q4VC44

Source protein: FLYWCH-type zinc finger-containing protein 1

Source gene: FLYWCH1

Class: DEG_APCC_DBOX_1

Location: 186:194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.951

ASA_SCORE: 81.5556

COIL: 0.667

CONS_SCORE: 0.6638

DSS_SCORE: 0.6834

HELIX: 0.2177

FCONS_SCORE: 1.1467

RIG_SCORE: 0.6851

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G180R	DO7990	COAD	ICGC	QREKLPSLA	DEG_APCC_DBOX_1	0.1667
p.R185H	DO227802	COCA	ICGC	QREKLPSLA	DEG_APCC_DBOX_1	0.3056
p.R184Q	DO28823	OV	ICGC	QREKLPSLA	DEG_APCC_DBOX_1	0.2778
p.R184Q	SIDM01088	Endometrial Carcinoma	GDSC	QREKLPSLA	DEG_APCC_DBOX_1	0.2778
p.R184Q	ACH-000965	Endometrial/Uterine Cancer	CCLE	QREKLPSLA	DEG_APCC_DBOX_1	0.2778
p.S192G	DO229268	THCA	ICGC	QREKLPSLA	DEG_APCC_DBOX_1	0.6993
p.E197V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	QREKLPSLA	DEG_APCC_DBOX_1	0.25
p.E197V	SIDM00793	Burkitt's Lymphoma	GDSC	QREKLPSLA	DEG_APCC_DBOX_1	0.25
p.E197V	SIDM00621	Ewing's Sarcoma	GDSC	QREKLPSLA	DEG_APCC_DBOX_1	0.25
p.E197V	SIDM00314	Breast Carcinoma	GDSC	QREKLPSLA	DEG_APCC_DBOX_1	0.25
p.R184C	ACH-001516	Cervical Cancer	CCLE	QREKLPSLA	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4VC44	FLYWCH-type zinc finger-containing protein 1	DEG_APCC_DBOX_1	186:194	QREKLPSLA	APC,CDC20,FZR1	0.951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons