DegronMD - Q4VX76(SYTL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R404Q	TCGA-BR-4201	STAD	TCGA	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.6218
p.R404Q	SIDM00309	Mesothelioma	GDSC	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.6218
p.A403T	TCGA-D1-A103	UCEC	TCGA	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.3056
p.G409E	TCGA-DX-A7EM	SARC	TCGA	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.6087
p.L408F	TCGA-PQ-A6FN	BLCA	TCGA	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.6981
p.Q407E	DO219064	BLCA	ICGC	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.6744
p.R396K	DO456	BLCA	ICGC	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.1111
p.G412C	DO229036	LICA	ICGC	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.76
p.K422N	DO49073	UCEC	ICGC	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.0556
p.K422N	DO41211	UCEC	ICGC	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.0556
p.K422N	PANC-08-13	pancreas	COSMIC	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.0556
p.R404W	SIDM00798	Rhabdomyosarcoma	GDSC	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.7523
p.R404W	ACH-000201	Rhabdoid	CCLE	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.7523
p.R404W	ACH-001212	Rhabdoid	CCLE	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.7523
p.R404W	A204	soft tissue	COSMIC	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation altering degron motif	0.7523
p.T401M	SIDM01463	Endometrial Carcinoma	GDSC	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation blocking phosphorylation signal	0.6944
p.A403D	ACH-000851	Lung Cancer	CCLE	RRVFLGEVI	DEG_APCC_DBOX_1	404:412	Mutation rewiring degron network	0.3056

Kaplan plot for SYTL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYTL3

UniProt ID: Q4VX76

Entrez ID: 94120

Protein name: Synaptotagmin-like protein 3 (Exophilin-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYTL3 in