DegronMD

Uniprot ID: Q4VX76

Source protein: Synaptotagmin-like protein 3

Source gene: SYTL3

Class: DEG_APCC_DBOX_1

Location: 404:412

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7764

ASA_SCORE: 60.1333

COIL: 0.358

CONS_SCORE: 0.7144

DSS_SCORE: 0.0148

HELIX: 0.0327

FCONS_SCORE: 1.3076

RIG_SCORE: 0.9327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R404Q	TCGA-BR-4201	STAD	TCGA	RRVFLGEVI	DEG_APCC_DBOX_1	0.6218
p.R404Q	SIDM00309	Mesothelioma	GDSC	RRVFLGEVI	DEG_APCC_DBOX_1	0.6218
p.A403T	TCGA-D1-A103	UCEC	TCGA	RRVFLGEVI	DEG_APCC_DBOX_1	0.3056
p.G409E	TCGA-DX-A7EM	SARC	TCGA	RRVFLGEVI	DEG_APCC_DBOX_1	0.6087
p.L408F	TCGA-PQ-A6FN	BLCA	TCGA	RRVFLGEVI	DEG_APCC_DBOX_1	0.6981
p.Q407E	DO219064	BLCA	ICGC	RRVFLGEVI	DEG_APCC_DBOX_1	0.6744
p.R396K	DO456	BLCA	ICGC	RRVFLGEVI	DEG_APCC_DBOX_1	0.1111
p.G412C	DO229036	LICA	ICGC	RRVFLGEVI	DEG_APCC_DBOX_1	0.76
p.K422N	DO49073	UCEC	ICGC	RRVFLGEVI	DEG_APCC_DBOX_1	0.0556
p.K422N	DO41211	UCEC	ICGC	RRVFLGEVI	DEG_APCC_DBOX_1	0.0556
p.K422N	PANC-08-13	pancreas	COSMIC	RRVFLGEVI	DEG_APCC_DBOX_1	0.0556
p.R404W	SIDM00798	Rhabdomyosarcoma	GDSC	RRVFLGEVI	DEG_APCC_DBOX_1	0.7523
p.R404W	ACH-000201	Rhabdoid	CCLE	RRVFLGEVI	DEG_APCC_DBOX_1	0.7523
p.R404W	ACH-001212	Rhabdoid	CCLE	RRVFLGEVI	DEG_APCC_DBOX_1	0.7523
p.R404W	A204	soft_tissue	COSMIC	RRVFLGEVI	DEG_APCC_DBOX_1	0.7523
p.T401M	SIDM01463	Endometrial Carcinoma	GDSC	RRVFLGEVI	DEG_APCC_DBOX_1	0.6944
p.A403D	ACH-000851	Lung Cancer	CCLE	RRVFLGEVI	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4VX76	Synaptotagmin-like protein 3	DEG_APCC_DBOX_1	404:412	RRVFLGEVI	APC,CDC20,FZR1	0.7764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons