DegronMD - Q4ZIN3(TMEM259)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V142L	TCGA-60-2726	LUSC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1667
p.V142L	DO27484	LUSC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1667
p.V142L	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1667
p.V142L	ACH-000563	Lung Cancer	CCLE	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1667
p.V142L	EBC-1	lung	COSMIC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1667
p.G132V	TCGA-85-8287	LUSC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.7532
p.G132V	DO27492	LUSC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.7532
p.G133S	TCGA-BR-6566	STAD	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.5882
p.G133S	DO38217	STAD	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.5882
p.R121C	TCGA-CM-6167	COAD	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.0833
p.R121C	DO10212	COAD	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.0833
p.R121C	DO42256	UCEC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.0833
p.P138S	TCGA-DX-A8BP	SARC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.2778
p.P138S	DO220056	SARC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.2778
p.G135R	TCGA-EO-A22U	UCEC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.6457
p.G135R	DO43755	UCEC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.6457
p.G135R	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.6457
p.G135R	ACH-000917	Esophageal Cancer	CCLE	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.6457
p.G135R	TE-4	oesophagus	COSMIC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.6457
p.A122V	TCGA-EO-A22U	UCEC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1111
p.A122V	DO43755	UCEC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1111
p.S146N	TCGA-FA-A7Q1	DLBC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.0556
p.S146N	DO219890	DLBC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.0556
p.P138T	TCGA-FS-A1ZP	SKCM	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.2778
p.P138T	DO37703	SKCM	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.2778
p.A141V	TCGA-GF-A6C9	SKCM	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1944
p.A141V	DO51254	SKCM	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1944
p.V124I	DO227987	COCA	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1667
p.V142M	DO222765	COCA	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1667
p.G139D	DO50970	LICA	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.25
p.A122T	SIDM01161	Other Sarcomas	GDSC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.1111
p.S131I	SIDM01097	Other Solid Cancers	GDSC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.7341
p.S131I	ACH-001193	Bone Cancer	CCLE	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.7341
p.S131I	SK-PN-DW	bone	COSMIC	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation altering degron motif	0.7341
p.S146R	ACH-000923	Lymphoma	CCLE	DSGGRGS	DEG_SCF_TRCP1_1	130:136	Mutation rewiring degron network	0.0556

Kaplan plot for TMEM259 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM259

UniProt ID: Q4ZIN3

Entrez ID: 91304

Protein name: Membralin (Transmembrane protein 259)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM259 in