DegronMD

Uniprot ID: Q4ZIN3

Source protein: Membralin

Source gene: TMEM259

Class: DEG_SCF_TRCP1_1

Location: 130:136

E3 ligase: BTRC

DEGRON score: 0.9281

ASA_SCORE: 64.4286

COIL: 0.8017

CONS_SCORE: 0.2911

DSS_SCORE: 0.3631

HELIX: 0.0424

FCONS_SCORE: 0.8919

RIG_SCORE: 0.6194

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V142L	TCGA-60-2726	LUSC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	0.1667
p.V142L	DO27484	LUSC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.1667
p.V142L	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DSGGRGS	DEG_SCF_TRCP1_1	0.1667
p.V142L	ACH-000563	Lung Cancer	CCLE	DSGGRGS	DEG_SCF_TRCP1_1	0.1667
p.V142L	EBC-1	lung	COSMIC	DSGGRGS	DEG_SCF_TRCP1_1	0.1667
p.G132V	TCGA-85-8287	LUSC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	0.7532
p.G132V	DO27492	LUSC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.7532
p.G133S	TCGA-BR-6566	STAD	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	0.5882
p.G133S	DO38217	STAD	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.5882
p.R121C	TCGA-CM-6167	COAD	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	0.0833
p.R121C	DO10212	COAD	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.0833
p.R121C	DO42256	UCEC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.0833
p.P138S	TCGA-DX-A8BP	SARC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	0.2778
p.P138S	DO220056	SARC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.2778
p.G135R	TCGA-EO-A22U	UCEC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	0.6457
p.G135R	DO43755	UCEC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.6457
p.G135R	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DSGGRGS	DEG_SCF_TRCP1_1	0.6457
p.G135R	ACH-000917	Esophageal Cancer	CCLE	DSGGRGS	DEG_SCF_TRCP1_1	0.6457
p.G135R	TE-4	oesophagus	COSMIC	DSGGRGS	DEG_SCF_TRCP1_1	0.6457
p.A122V	TCGA-EO-A22U	UCEC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	0.1111
p.A122V	DO43755	UCEC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.1111
p.S146N	TCGA-FA-A7Q1	DLBC	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	0.0556
p.S146N	DO219890	DLBC	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.0556
p.P138T	TCGA-FS-A1ZP	SKCM	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	0.2778
p.P138T	DO37703	SKCM	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.2778
p.A141V	TCGA-GF-A6C9	SKCM	TCGA	DSGGRGS	DEG_SCF_TRCP1_1	0.1944
p.A141V	DO51254	SKCM	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.1944
p.V124I	DO227987	COCA	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.1667
p.V142M	DO222765	COCA	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.1667
p.G139D	DO50970	LICA	ICGC	DSGGRGS	DEG_SCF_TRCP1_1	0.25
p.A122T	SIDM01161	Other Sarcomas	GDSC	DSGGRGS	DEG_SCF_TRCP1_1	0.1111
p.S131I	SIDM01097	Other Solid Cancers	GDSC	DSGGRGS	DEG_SCF_TRCP1_1	0.7341
p.S131I	ACH-001193	Bone Cancer	CCLE	DSGGRGS	DEG_SCF_TRCP1_1	0.7341
p.S131I	SK-PN-DW	bone	COSMIC	DSGGRGS	DEG_SCF_TRCP1_1	0.7341
p.S146R	ACH-000923	Lymphoma	CCLE	DSGGRGS	DEG_SCF_TRCP1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGGRGS

Degron related mutations and impact score

Drug responses associated with TMEM259 mutations

All proteins holding degron of DSGGRGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4ZIN3	Membralin	DEG_SCF_TRCP1_1	130:136	DSGGRGS	BTRC	0.9281	More...