DegronMD - Q502W6(VWA3B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H768Q	TCGA-39-5021	LUSC	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.7582
p.H768Q	TCGA-CR-7371	HNSC	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.7582
p.H768Q	DO15454	HNSC	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.7582
p.H768Q	DO27397	LUSC	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.7582
p.R778G	TCGA-49-4507	LUAD	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation rewiring degron network	0.1111
p.R778G	DO25727	LUAD	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation rewiring degron network	0.1111
p.V761A	TCGA-AG-A002	READ	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation rewiring degron network	0.25
p.S757P	TCGA-B5-A0K6	UCEC	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation rewiring degron network	0.1389
p.S757P	DO40808	UCEC	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation rewiring degron network	0.1389
p.W754S	TCGA-BT-A20T	BLCA	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation rewiring degron network	0.0556
p.W754S	DO804	BLCA	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation rewiring degron network	0.0556
p.W754G	TCGA-D3-A2JH	SKCM	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation rewiring degron network	0.0556
p.W754G	DO47263	SKCM	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation rewiring degron network	0.0556
p.A769S	TCGA-MA-AA3W	CESC	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.6477
p.A769S	DO219719	CESC	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.6477
p.A769T	SIDM00121	T-Lymphoblastic Leukemia	GDSC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.6028
p.A769T	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.6028
p.A769T	ACH-000371	Lymphoma	CCLE	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.6028
p.A769T	ACH-001738	Leukemia	CCLE	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.6028
p.A769T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.6028
p.A769T	RL	haematopoietic and lymphoid tissue	COSMIC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.6028
p.H768Y	ACH-002041	Thyroid Cancer	CCLE	KKVLHAE	LIG_APCC_ABBAyCdc20_2	764:770	Mutation altering degron motif	0.6118

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VWA3B

UniProt ID: Q502W6

Entrez ID: 200403

Protein name: von Willebrand factor A domain-containing protein 3B (VWA domain-containing protein 3B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VWA3B in