DegronMD

Uniprot ID: Q502W6

Source protein: von Willebrand factor A domain-containing protein 3B

Source gene: VWA3B

Class: LIG_APCC_ABBAyCdc20_2

Location: 764:770

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7158

ASA_SCORE: 101.2429

COIL: 0.4211

CONS_SCORE: 0.3866

DSS_SCORE: 0.4991

HELIX: 0.5179

FCONS_SCORE: 1.0372

RIG_SCORE: 0.7658

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H768Q	TCGA-39-5021	LUSC	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.7582
p.H768Q	TCGA-CR-7371	HNSC	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.7582
p.H768Q	DO15454	HNSC	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.7582
p.H768Q	DO27397	LUSC	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.7582
p.R778G	TCGA-49-4507	LUAD	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R778G	DO25727	LUAD	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.V761A	TCGA-AG-A002	READ	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.25
p.S757P	TCGA-B5-A0K6	UCEC	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S757P	DO40808	UCEC	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.W754S	TCGA-BT-A20T	BLCA	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.W754S	DO804	BLCA	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.W754G	TCGA-D3-A2JH	SKCM	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.W754G	DO47263	SKCM	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A769S	TCGA-MA-AA3W	CESC	TCGA	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.6477
p.A769S	DO219719	CESC	ICGC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.6477
p.A769T	SIDM00121	T-Lymphoblastic Leukemia	GDSC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.6028
p.A769T	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.6028
p.A769T	ACH-000371	Lymphoma	CCLE	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.6028
p.A769T	ACH-001738	Leukemia	CCLE	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.6028
p.A769T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.6028
p.A769T	RL	haematopoietic_and_lymphoid_tissue	COSMIC	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.6028
p.H768Y	ACH-002041	Thyroid Cancer	CCLE	KKVLHAE	LIG_APCC_ABBAyCdc20_2	0.6118

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q502W6	von Willebrand factor A domain-containing protein 3B	LIG_APCC_ABBAyCdc20_2	764:770	KKVLHAE	APC,CDC20,FZR1	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons