DegronMD - Q504Y3(ZCWPW2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P287S	TCGA-A5-A0G1	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.6752
p.P287S	DO42472	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.6752
p.S290L	TCGA-A5-A0G1	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.7667
p.S290L	DO42472	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.7667
p.A285V	TCGA-A5-A0G2	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.5825
p.A285V	DO41235	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.5825
p.Q278H	TCGA-AP-A0LM	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1944
p.Q278H	DO43306	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1944
p.E296G	TCGA-B5-A1MX	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1667
p.E296G	DO41999	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1667
p.M276T	TCGA-BR-4361	STAD	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1389
p.M276T	DO38887	STAD	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1389
p.G293E	TCGA-E2-A10C	BRCA	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.25
p.G293E	DO1334	BRCA	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.25
p.G295R	TCGA-EE-A181	SKCM	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1944
p.G295R	DO37444	SKCM	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1944
p.A285T	TCGA-EO-A3KX	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.6028
p.A285T	TCGA-XK-AAIW	PRAD	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.6028
p.A285T	DO51407	PRAD	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.6028
p.A285T	DO219774	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.6028
p.E296D	TCGA-RD-A8NB	STAD	TCGA	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1667
p.E296D	DO233650	GACA	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1667
p.E296D	DO50142	STAD	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1667
p.E296D	SIDM01619	Endometrial Carcinoma	GDSC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1667
p.E296D	ACH-000984	Endometrial/Uterine Cancer	CCLE	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1667
p.M300I	DO229034	LICA	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.0556
p.H294Y	DO229054	LICA	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.2222
p.H294R	DO229054	LICA	ICGC	PTATPDES	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.2222

Kaplan plot for ZCWPW2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZCWPW2

UniProt ID: Q504Y3

Entrez ID: 152098

Protein name: Zinc finger CW-type PWWP domain protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZCWPW2 in