DegronMD

Uniprot ID: Q504Y3

Source protein: Zinc finger CW-type PWWP domain protein 2

Source gene: ZCWPW2

Class: DEG_SCF_FBW7_1

Location: 283:290

E3 ligase: FBXW7

DEGRON score: 0.8353

ASA_SCORE: 85.0125

COIL: 0.8679

CONS_SCORE: 0.5507

DSS_SCORE: 0.7423

HELIX: 0.0981

FCONS_SCORE: 1.1482

RIG_SCORE: 0.6418

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P287S	TCGA-A5-A0G1	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.6752
p.P287S	DO42472	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.6752
p.S290L	TCGA-A5-A0G1	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.7667
p.S290L	DO42472	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.7667
p.A285V	TCGA-A5-A0G2	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.5825
p.A285V	DO41235	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.5825
p.Q278H	TCGA-AP-A0LM	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.1944
p.Q278H	DO43306	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.1944
p.E296G	TCGA-B5-A1MX	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.1667
p.E296G	DO41999	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.1667
p.M276T	TCGA-BR-4361	STAD	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.1389
p.M276T	DO38887	STAD	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.1389
p.G293E	TCGA-E2-A10C	BRCA	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.25
p.G293E	DO1334	BRCA	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.25
p.G295R	TCGA-EE-A181	SKCM	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.1944
p.G295R	DO37444	SKCM	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.1944
p.A285T	TCGA-EO-A3KX	UCEC	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.6028
p.A285T	TCGA-XK-AAIW	PRAD	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.6028
p.A285T	DO51407	PRAD	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.6028
p.A285T	DO219774	UCEC	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.6028
p.E296D	TCGA-RD-A8NB	STAD	TCGA	PTATPDES	DEG_SCF_FBW7_1	0.1667
p.E296D	DO233650	GACA	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.1667
p.E296D	DO50142	STAD	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.1667
p.E296D	SIDM01619	Endometrial Carcinoma	GDSC	PTATPDES	DEG_SCF_FBW7_1	0.1667
p.E296D	ACH-000984	Endometrial/Uterine Cancer	CCLE	PTATPDES	DEG_SCF_FBW7_1	0.1667
p.M300I	DO229034	LICA	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.0556
p.H294Y	DO229054	LICA	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.2222
p.H294R	DO229054	LICA	ICGC	PTATPDES	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q504Y3	Zinc finger CW-type PWWP domain protein 2	DEG_SCF_FBW7_1	283:290	PTATPDES	FBXW7	0.8353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTATPDES

Degron related mutations and impact score

Drug responses associated with ZCWPW2 mutations

All proteins holding degron of PTATPDES