DegronMD - Q52LD8(RFTN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E325Q	TCGA-39-5030	LUSC	TCGA	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation altering degron motif	0.6744
p.E325Q	DO27176	LUSC	ICGC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation altering degron motif	0.6744
p.S333Y	TCGA-CA-6717	COAD	TCGA	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1111
p.S333Y	DO8264	COAD	ICGC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1111
p.S334C	DO225065	BRCA	ICGC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation blocking phosphorylation signal	0.5278
p.S333C	DO225363	BRCA	ICGC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1111
p.P331S	DO222762	COCA	ICGC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1667
p.S334G	DO233882	GACA	ICGC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation blocking phosphorylation signal	0.5278
p.P331T	DO229027	LICA	ICGC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation rewiring degron network	0.1667
p.S334R	SIDM01179	Other Sarcomas	GDSC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation blocking phosphorylation signal	0.5278
p.S334R	SIDM00652	Small Cell Lung Carcinoma	GDSC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation blocking phosphorylation signal	0.5278
p.S334R	SIDM00317	Kidney Carcinoma	GDSC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation blocking phosphorylation signal	0.5278
p.S334R	SIDM00476	Ovarian Carcinoma	GDSC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation blocking phosphorylation signal	0.5278
p.S334R	SIDM00677	Colorectal Carcinoma	GDSC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation blocking phosphorylation signal	0.5278
p.S334R	SIDM01749	Osteosarcoma	GDSC	FFIYEE	LIG_APCC_ABBA_1	320:325	Mutation blocking phosphorylation signal	0.5278

Kaplan plot for RFTN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFTN2

UniProt ID: Q52LD8

Entrez ID: 130132

Protein name: Raftlin-2 (Raft-linking protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFTN2 in