DegronMD

Uniprot ID: Q52LD8

Source protein: Raftlin-2

Source gene: RFTN2

Class: LIG_APCC_ABBA_1

Location: 320:325

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.554

ASA_SCORE: 43.5333

COIL: 0.1727

CONS_SCORE: 0.8969

DSS_SCORE: 0.3205

HELIX: 0.0135

FCONS_SCORE: 1.1677

RIG_SCORE: 0.8458

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E325Q	TCGA-39-5030	LUSC	TCGA	FFIYEE	LIG_APCC_ABBA_1	0.6744
p.E325Q	DO27176	LUSC	ICGC	FFIYEE	LIG_APCC_ABBA_1	0.6744
p.S333Y	TCGA-CA-6717	COAD	TCGA	FFIYEE	LIG_APCC_ABBA_1	0.1111
p.S333Y	DO8264	COAD	ICGC	FFIYEE	LIG_APCC_ABBA_1	0.1111
p.S334C	DO225065	BRCA	ICGC	FFIYEE	LIG_APCC_ABBA_1	0.5278
p.S333C	DO225363	BRCA	ICGC	FFIYEE	LIG_APCC_ABBA_1	0.1111
p.P331S	DO222762	COCA	ICGC	FFIYEE	LIG_APCC_ABBA_1	0.1667
p.S334G	DO233882	GACA	ICGC	FFIYEE	LIG_APCC_ABBA_1	0.5278
p.P331T	DO229027	LICA	ICGC	FFIYEE	LIG_APCC_ABBA_1	0.1667
p.S334R	SIDM01179	Other Sarcomas	GDSC	FFIYEE	LIG_APCC_ABBA_1	0.5278
p.S334R	SIDM00652	Small Cell Lung Carcinoma	GDSC	FFIYEE	LIG_APCC_ABBA_1	0.5278
p.S334R	SIDM00317	Kidney Carcinoma	GDSC	FFIYEE	LIG_APCC_ABBA_1	0.5278
p.S334R	SIDM00476	Ovarian Carcinoma	GDSC	FFIYEE	LIG_APCC_ABBA_1	0.5278
p.S334R	SIDM00677	Colorectal Carcinoma	GDSC	FFIYEE	LIG_APCC_ABBA_1	0.5278
p.S334R	SIDM01749	Osteosarcoma	GDSC	FFIYEE	LIG_APCC_ABBA_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q52LD8	Raftlin-2	LIG_APCC_ABBA_1	320:325	FFIYEE	APC,CDC20,FZR1	0.554	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons