DegronMD - Q53EV4(LRRC23)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E38Q	TCGA-78-7149	LUAD	TCGA	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1667
p.E38Q	TCGA-DK-AA6L	BLCA	TCGA	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1667
p.E38Q	DO219002	BLCA	ICGC	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1667
p.E38Q	DO23790	LUAD	ICGC	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1667
p.G36R	TCGA-85-8584	LUSC	TCGA	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1111
p.G36R	DO45438	LUSC	ICGC	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1111
p.E41K	TCGA-93-8067	LUAD	TCGA	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.25
p.E41K	DO25113	LUAD	ICGC	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.25
p.F39L	TCGA-A5-A0G2	UCEC	TCGA	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1944
p.F39L	TCGA-D8-A1Y0	BRCA	TCGA	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1944
p.F39L	DO3376	BRCA	ICGC	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1944
p.F39L	DO41235	UCEC	ICGC	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1944
p.P45S	DO50884	LICA	ICGC	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation altering degron motif	0.5641
p.P47L	DO38404	STAD	ICGC	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation altering degron motif	0.7582
p.G56W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1667
p.G56W	ACH-000995	Leukemia	CCLE	LPTPLTE	DEG_SCF_FBW7_2	44:50	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons