DegronMD

Uniprot ID: Q53EV4

Source protein: Leucine-rich repeat-containing protein 23

Source gene: LRRC23

Class: DEG_SCF_FBW7_2

Location: 44:50

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 61.7571

COIL: 0.7611

CONS_SCORE: 0.714

DSS_SCORE: 0.6047

HELIX: 0.1536

FCONS_SCORE: 1.0445

RIG_SCORE: 0.7959

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E38Q	TCGA-78-7149	LUAD	TCGA	LPTPLTE	DEG_SCF_FBW7_2	0.1667
p.E38Q	TCGA-DK-AA6L	BLCA	TCGA	LPTPLTE	DEG_SCF_FBW7_2	0.1667
p.E38Q	DO219002	BLCA	ICGC	LPTPLTE	DEG_SCF_FBW7_2	0.1667
p.E38Q	DO23790	LUAD	ICGC	LPTPLTE	DEG_SCF_FBW7_2	0.1667
p.G36R	TCGA-85-8584	LUSC	TCGA	LPTPLTE	DEG_SCF_FBW7_2	0.1111
p.G36R	DO45438	LUSC	ICGC	LPTPLTE	DEG_SCF_FBW7_2	0.1111
p.E41K	TCGA-93-8067	LUAD	TCGA	LPTPLTE	DEG_SCF_FBW7_2	0.25
p.E41K	DO25113	LUAD	ICGC	LPTPLTE	DEG_SCF_FBW7_2	0.25
p.F39L	TCGA-A5-A0G2	UCEC	TCGA	LPTPLTE	DEG_SCF_FBW7_2	0.1944
p.F39L	TCGA-D8-A1Y0	BRCA	TCGA	LPTPLTE	DEG_SCF_FBW7_2	0.1944
p.F39L	DO3376	BRCA	ICGC	LPTPLTE	DEG_SCF_FBW7_2	0.1944
p.F39L	DO41235	UCEC	ICGC	LPTPLTE	DEG_SCF_FBW7_2	0.1944
p.P45S	DO50884	LICA	ICGC	LPTPLTE	DEG_SCF_FBW7_2	0.5641
p.P47L	DO38404	STAD	ICGC	LPTPLTE	DEG_SCF_FBW7_2	0.7582
p.G56W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LPTPLTE	DEG_SCF_FBW7_2	0.1667
p.G56W	ACH-000995	Leukemia	CCLE	LPTPLTE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53EV4	Leucine-rich repeat-containing protein 23	DEG_SCF_FBW7_2	44:50	LPTPLTE	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons