DegronMD - Q53GS7(GLE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T74M	TCGA-77-A5GH	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.7423
p.S70L	TCGA-AA-3861	COAD	TCGA	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.S70L	TCGA-FI-A2D5	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.E62K	TCGA-AR-A250	BRCA	TCGA	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0833
p.E62K	DO1802	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0833
p.A78T	TCGA-AX-A0J1	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.25
p.A78T	DO41199	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.25
p.S96F	TCGA-EB-A3Y7	SKCM	TCGA	PATPNGT	DEG_SCF_FBW7_1	100:106	Mutation blocking phosphorylation signal	0.6667
p.S96F	DO37499	SKCM	ICGC	PATPNGT	DEG_SCF_FBW7_1	100:106	Mutation blocking phosphorylation signal	0.6667
p.P65L	TCGA-GN-A8LK	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1667
p.P65L	DO51259	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1667
p.S67C	TCGA-OR-A5K5	ACC	TCGA	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2222
p.S92G	TCGA-OR-A5K5	ACC	TCGA	PATPNGT	DEG_SCF_FBW7_1	100:106	Mutation blocking phosphorylation signal	0.5556
p.M99I	DO225195	BRCA	ICGC	PATPNGT	DEG_SCF_FBW7_1	100:106	Mutation blocking phosphorylation signal	0.75
p.R62Q	DO2983	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0833
p.M69I	DO229009	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.E108G	DO44974	LIHC	ICGC	PATPNGT	DEG_SCF_FBW7_1	100:106	Mutation rewiring degron network	0.2778
p.K82N	DO26423	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1389
p.Q101H	DO26423	LUSC	ICGC	PATPNGT	DEG_SCF_FBW7_1	100:106	Mutation altering degron motif	0.7582
p.A78V	DO27588	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.25
p.D81E	DO46404	OV	ICGC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1667
p.R62W	DO232224	PBCA	ICGC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0833
p.Q101K	DO229227	THCA	ICGC	PATPNGT	DEG_SCF_FBW7_1	100:106	Mutation altering degron motif	0.6944
p.H114N	DO229221	THCA	ICGC	PATPNGT	DEG_SCF_FBW7_1	100:106	Mutation rewiring degron network	0.1111
p.S67F	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2222
p.S67F	ACH-000983	Leukemia	CCLE	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2222
p.S67F	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2222
p.S83L	SIDM00140	Melanoma	GDSC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.S83L	ACH-000968	Skin Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.S83L	ACH-001484	Leukemia	CCLE	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.S83L	ACH-001485	Leukemia	CCLE	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.S83L	COLO-792	skin	COSMIC	PSSTS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.P100S	SIDM01768	Melanoma	GDSC	PATPNGT	DEG_SCF_FBW7_1	100:106	Mutation altering degron motif	0.6752
p.P100S	ACH-000899	Skin Cancer	CCLE	PATPNGT	DEG_SCF_FBW7_1	100:106	Mutation altering degron motif	0.6752

Kaplan plot for GLE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLE1

UniProt ID: Q53GS7

Entrez ID: 2733

Protein name: mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLE1 in