DegronMD

Uniprot ID: Q53GS7

Source protein: mRNA export factor GLE1

Source gene: GLE1

Class: DEG_SCF_FBW7_1

Location: 100:106

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 82.3286

COIL: 0.9267

CONS_SCORE: 0.3024

DSS_SCORE: 0.7171

HELIX: 0.0313

FCONS_SCORE: 1.0632

RIG_SCORE: 0.5277

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q101H	DO26423	LUSC	ICGC	PATPNGT	DEG_SCF_FBW7_1	0.7582
p.M99I	DO225195	BRCA	ICGC	PATPNGT	DEG_SCF_FBW7_1	0.75
p.Q101K	DO229227	THCA	ICGC	PATPNGT	DEG_SCF_FBW7_1	0.6944
p.P100S	SIDM01768	Melanoma	GDSC	PATPNGT	DEG_SCF_FBW7_1	0.6752
p.P100S	ACH-000899	Skin Cancer	CCLE	PATPNGT	DEG_SCF_FBW7_1	0.6752
p.S96F	TCGA-EB-A3Y7	SKCM	TCGA	PATPNGT	DEG_SCF_FBW7_1	0.6667
p.S96F	DO37499	SKCM	ICGC	PATPNGT	DEG_SCF_FBW7_1	0.6667
p.S92G	TCGA-OR-A5K5	ACC	TCGA	PATPNGT	DEG_SCF_FBW7_1	0.5556
p.E108G	DO44974	LIHC	ICGC	PATPNGT	DEG_SCF_FBW7_1	0.2778
p.H114N	DO229221	THCA	ICGC	PATPNGT	DEG_SCF_FBW7_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53GS7	mRNA export factor GLE1	DEG_SCF_FBW7_1	100:106	PATPNGT	FBXW7	0.9978	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons