DegronMD - Q53H96(PYCR3)

FUNCTION: Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. {ECO:0000269|PubMed:23024808}.

GO - Biological processes (BP): L-proline biosynthetic process [GO:0055129]

GO - Molecular function (MF): pyrroline-5-carboxylate reductase activity [GO:0004735]

GO - Cellular component (CC): cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G236C	SIDM01608	Endometrial Carcinoma	GDSC	VCTPGGT	DEG_SCF_FBW7_1	234:240	Mutation altering degron motif	0.76
p.R234Q	SNU-407	large intestine	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	234:240	Mutation altering degron motif	0.7329
p.A240T	C-33-A	cervix	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	234:240	Mutation altering degron motif	0.7139
p.L233M	AM-38	central nervous system	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	234:240	Mutation rewiring degron network	0.3056
p.R243H	SIDM00217	Colorectal Carcinoma	GDSC	VCTPGGT	DEG_SCF_FBW7_1	234:240	Mutation rewiring degron network	0.25
p.R243H	SNU-1040	large intestine	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	234:240	Mutation rewiring degron network	0.25
p.R231H	SNU-1040	large intestine	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	234:240	Mutation rewiring degron network	0.25
p.E229Q	BT-483	breast	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	234:240	Mutation rewiring degron network	0.1944
p.E249Q	BT-483	breast	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	234:240	Mutation rewiring degron network	0.0833

Showing 1 to 9 of 9 entries

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No resistance data available for this Degron.

Kaplan plot for PYCR3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PYCR3

UniProt ID: Q53H96

Entrez ID: 65263

Protein name: Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for PYCR3 in