DegronMD

Uniprot ID: Q53H96

Source protein: Pyrroline-5-carboxylate reductase 3

Source gene: PYCR3

Class: DEG_SCF_FBW7_1

Location: 234:240

E3 ligase: FBXW7

DEGRON score: 0.8282

ASA_SCORE: 29.2

COIL: 0.6526

CONS_SCORE: 0.7657

DSS_SCORE: 0.3031

HELIX: 0.3231

FCONS_SCORE: 1.3289

RIG_SCORE: 0.7118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R243H	SIDM00217	Colorectal Carcinoma	GDSC	VCTPGGT	DEG_SCF_FBW7_1	0.25
p.R243H	SNU-1040	large_intestine	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	0.25
p.G236C	SIDM01608	Endometrial Carcinoma	GDSC	VCTPGGT	DEG_SCF_FBW7_1	0.76
p.A240T	C-33-A	cervix	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	0.7139
p.R231H	SNU-1040	large_intestine	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	0.25
p.E249Q	BT-483	breast	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	0.0833
p.E229Q	BT-483	breast	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	0.1944
p.R234Q	SNU-407	large_intestine	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	0.7329
p.L233M	AM-38	central_nervous_system	COSMIC	VCTPGGT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53H96	Pyrroline-5-carboxylate reductase 3	DEG_SCF_FBW7_1	234:240	VCTPGGT	FBXW7	0.8282	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons