DegronMD - Q53QZ3(ARHGAP15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L265M	TCGA-58-A46J	LUSC	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.711
p.L265M	DO45532	LUSC	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.711
p.L265V	TCGA-78-7633	LUAD	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6765
p.L265V	DO24359	LUAD	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6765
p.K275E	TCGA-A8-A09C	BRCA	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation blocking ubiquitination signal	0.6111
p.K275E	DO3358	BRCA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation blocking ubiquitination signal	0.6111
p.T267N	TCGA-B5-A0JY	UCEC	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.5944
p.T267N	DO43041	UCEC	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.5944
p.T267P	TCGA-BR-4366	STAD	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.5919
p.T267P	DO233897	GACA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.5919
p.T267P	DO38419	STAD	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.5919
p.K256N	TCGA-BS-A0UF	UCEC	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation substituting flanking lysine	0.3056
p.K256N	DO41488	UCEC	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation substituting flanking lysine	0.3056
p.R262I	TCGA-F5-6814	READ	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.8102
p.R262I	DO36556	READ	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.8102
p.K271Q	TCGA-OR-A5K5	ACC	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation blocking ubiquitination signal	0.7222
p.G272E	TCGA-VQ-A8P2	STAD	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.25
p.G272E	DO51761	STAD	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.25
p.L265Q	DO224680	BRCA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.7765
p.K257T	DO233274	GACA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation substituting flanking lysine	0.3333
p.L273P	DO233874	GACA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.2222
p.I278F	DO233855	GACA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.0833
p.K252E	SIDM01043	Other Sarcomas	GDSC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation substituting flanking lysine	0.1944
p.K252E	ACH-000913	Endometrial/Uterine Cancer	CCLE	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation substituting flanking lysine	0.1944
p.K252E	ESS-1	endometrium	COSMIC	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation substituting flanking lysine	0.1944
p.K271I	ACH-000779	Lung Cancer	CCLE	RRPSLKTLQ	DEG_APCC_DBOX_1	261:269	Mutation blocking ubiquitination signal	0.7222

Kaplan plot for ARHGAP15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP15

UniProt ID: Q53QZ3

Entrez ID: 55843

Protein name: Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP15 in