DegronMD

Uniprot ID: Q53QZ3

Source protein: Rho GTPase-activating protein 15

Source gene: ARHGAP15

Class: DEG_APCC_DBOX_1

Location: 261:269

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6371

ASA_SCORE: 92.8778

COIL: 0.6157

CONS_SCORE: 0.4935

DSS_SCORE: 0.3647

HELIX: 0.36

FCONS_SCORE: 0.9604

RIG_SCORE: 0.7807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L265M	TCGA-58-A46J	LUSC	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	0.711
p.L265M	DO45532	LUSC	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.711
p.L265V	TCGA-78-7633	LUAD	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	0.6765
p.L265V	DO24359	LUAD	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.6765
p.K275E	TCGA-A8-A09C	BRCA	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	0.6111
p.K275E	DO3358	BRCA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.6111
p.T267N	TCGA-B5-A0JY	UCEC	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	0.5944
p.T267N	DO43041	UCEC	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.5944
p.T267P	TCGA-BR-4366	STAD	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	0.5919
p.T267P	DO233897	GACA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.5919
p.T267P	DO38419	STAD	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.5919
p.K256N	TCGA-BS-A0UF	UCEC	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	0.3056
p.K256N	DO41488	UCEC	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.3056
p.R262I	TCGA-F5-6814	READ	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	0.8102
p.R262I	DO36556	READ	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.8102
p.K271Q	TCGA-OR-A5K5	ACC	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	0.7222
p.G272E	TCGA-VQ-A8P2	STAD	TCGA	RRPSLKTLQ	DEG_APCC_DBOX_1	0.25
p.G272E	DO51761	STAD	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.25
p.L265Q	DO224680	BRCA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.7765
p.K257T	DO233274	GACA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.3333
p.L273P	DO233874	GACA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.2222
p.I278F	DO233855	GACA	ICGC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.0833
p.K252E	SIDM01043	Other Sarcomas	GDSC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.1944
p.K252E	ACH-000913	Endometrial/Uterine Cancer	CCLE	RRPSLKTLQ	DEG_APCC_DBOX_1	0.1944
p.K252E	ESS-1	endometrium	COSMIC	RRPSLKTLQ	DEG_APCC_DBOX_1	0.1944
p.K271I	ACH-000779	Lung Cancer	CCLE	RRPSLKTLQ	DEG_APCC_DBOX_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53QZ3	Rho GTPase-activating protein 15	DEG_APCC_DBOX_1	261:269	RRPSLKTLQ	APC,CDC20,FZR1	0.6371	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRPSLKTLQ

Degron related mutations and impact score

Drug responses associated with ARHGAP15 mutations

All proteins holding degron of RRPSLKTLQ