DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
C2CD6
UniProt ID:
Q53TS8
Entrez ID:
151254
Protein name:
C2 calcium-dependent domain-containing protein 6 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Open in full screen with detailed sequence annotations
C2CD6
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.M330T
SIDM00729
Non-Small Cell Lung Carcinoma
GDSC
PRERLEKMK
DEG_APCC_DBOX_1
323:331
Mutation altering degron motif
0.7423
p.M330T
SIDM01724
Melanoma
GDSC
PRERLEKMK
DEG_APCC_DBOX_1
323:331
Mutation altering degron motif
0.7423
p.R315Q
SNU-81
large intestine
COSMIC
PRERLEKMK
DEG_APCC_DBOX_1
323:331
Mutation rewiring degron network
0.1111
p.E325G
TASK1
bone
COSMIC
PRERLEKMK
DEG_APCC_DBOX_1
323:331
Mutation altering degron motif
0.6087
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for C2CD6 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc