DegronMD

Uniprot ID: Q53TS8

Source protein: C2 calcium-dependent domain-containing protein 6

Source gene: C2CD6

Class: DEG_APCC_DBOX_1

Location: 323:331

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9314

ASA_SCORE: 83.5778

COIL: 0.0617

CONS_SCORE: 0.6284

DSS_SCORE: 0.4721

HELIX: 0.9369

FCONS_SCORE: 1.2677

RIG_SCORE: 0.7734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M330T	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	PRERLEKMK	DEG_APCC_DBOX_1	0.7423
p.M330T	SIDM01724	Melanoma	GDSC	PRERLEKMK	DEG_APCC_DBOX_1	0.7423
p.R315Q	SNU-81	large_intestine	COSMIC	PRERLEKMK	DEG_APCC_DBOX_1	0.1111
p.E325G	TASK1	bone	COSMIC	PRERLEKMK	DEG_APCC_DBOX_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TS8	C2 calcium-dependent domain-containing protein 6	DEG_APCC_DBOX_1	323:331	PRERLEKMK	APC,CDC20,FZR1	0.9314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons