DegronMD - Q587J7(TDRD12)

TDRD12

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G334C	DO229015	LICA	ICGC	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.3056
p.A339S	DO229029	LICA	ICGC	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation altering degron motif	0.6477
p.A346T	SIDM00773	Non-Cancerous	GDSC	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.1667
p.A346T	SIDM00969	Ovarian Carcinoma	GDSC	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.1667
p.A346T	SIDM00774	Breast Carcinoma	GDSC	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.1667
p.I337M	SIDM00596	Endometrial Carcinoma	GDSC	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation altering degron motif	0.6507
p.I337M	ACH-001517	Endometrial/Uterine Cancer	CCLE	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation altering degron motif	0.6507
p.I337M	HEC-1	endometrium	COSMIC	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation altering degron motif	0.6507
p.S325Y	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.0556
p.S325Y	ACH-000672	Lung Cancer	CCLE	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.0556
p.S325Y	IA-LM	lung	COSMIC	ITIYAD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc