DegronMD

Uniprot ID: Q587J7

Source protein: Putative ATP-dependent RNA helicase TDRD12

Source gene: TDRD12

Class: LIG_APCC_ABBA_1

Location: 335:340

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8399

ASA_SCORE: 56.6667

COIL: 0.5108

CONS_SCORE: 0.42

DSS_SCORE: 0.3491

HELIX: 0.0292

FCONS_SCORE: 1.1491

RIG_SCORE: 0.7875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G334C	DO229015	LICA	ICGC	ITIYAD	LIG_APCC_ABBA_1	0.3056
p.A339S	DO229029	LICA	ICGC	ITIYAD	LIG_APCC_ABBA_1	0.6477
p.A346T	SIDM00773	Non-Cancerous	GDSC	ITIYAD	LIG_APCC_ABBA_1	0.1667
p.A346T	SIDM00969	Ovarian Carcinoma	GDSC	ITIYAD	LIG_APCC_ABBA_1	0.1667
p.A346T	SIDM00774	Breast Carcinoma	GDSC	ITIYAD	LIG_APCC_ABBA_1	0.1667
p.I337M	SIDM00596	Endometrial Carcinoma	GDSC	ITIYAD	LIG_APCC_ABBA_1	0.6507
p.I337M	ACH-001517	Endometrial/Uterine Cancer	CCLE	ITIYAD	LIG_APCC_ABBA_1	0.6507
p.I337M	HEC-1	endometrium	COSMIC	ITIYAD	LIG_APCC_ABBA_1	0.6507
p.S325Y	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	ITIYAD	LIG_APCC_ABBA_1	0.0556
p.S325Y	ACH-000672	Lung Cancer	CCLE	ITIYAD	LIG_APCC_ABBA_1	0.0556
p.S325Y	IA-LM	lung	COSMIC	ITIYAD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q587J7	Putative ATP-dependent RNA helicase TDRD12	LIG_APCC_ABBA_1	335:340	ITIYAD	APC,CDC20,FZR1	0.8399	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons