DegronMD - Q58DX5(NAALADL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S366C	TCGA-34-5236	LUSC	TCGA	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.2222
p.S366C	DO26778	LUSC	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.2222
p.E365K	TCGA-D3-A8GQ	SKCM	TCGA	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1944
p.E365K	DO51246	SKCM	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1944
p.V379M	TCGA-GN-A264	SKCM	TCGA	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.3056
p.V379M	DO37527	SKCM	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.3056
p.R371Q	TCGA-GN-A266	SKCM	TCGA	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation altering degron motif	0.7329
p.R371Q	DO229462	SKCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation altering degron motif	0.7329
p.R371Q	DO37432	SKCM	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation altering degron motif	0.7329
p.P385S	DO229010	COCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1389
p.P385S	DO229013	COCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1389
p.P385S	DO229016	COCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1389
p.P385S	DO229003	COCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1389
p.P385S	DO229005	COCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1389
p.P381S	DO234215	ESAD	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.25
p.T375I	DO233918	GACA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation altering degron motif	0.5966
p.S362G	DO228253	MALY	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1111
p.P385L	DO222702	MELA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1389
p.Y360C	DO222837	MELA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.0556
p.P381A	DO231284	PACA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.25
p.S376Y	DO51171	PAEN	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation altering degron motif	0.6009
p.P381L	SIDM00003	Melanoma	GDSC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.25
p.P381L	ACH-002159	Skin Cancer	CCLE	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.25
p.P381L	M14	skin	COSMIC	SRSNLTSLL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.25

Kaplan plot for NAALADL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NAALADL2

UniProt ID: Q58DX5

Entrez ID: 254827

Protein name: Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NAALADL2 in