DegronMD

Uniprot ID: Q58DX5

Source protein: Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

Source gene: NAALADL2

Class: DEG_APCC_DBOX_1

Location: 370:378

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7554

ASA_SCORE: 71.3889

COIL: 0.7058

CONS_SCORE: 0.3856

DSS_SCORE: 0.3984

HELIX: 0.2226

FCONS_SCORE: 0.9108

RIG_SCORE: 0.7428

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S366C	TCGA-34-5236	LUSC	TCGA	SRSNLTSLL	DEG_APCC_DBOX_1	0.2222
p.S366C	DO26778	LUSC	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.2222
p.E365K	TCGA-D3-A8GQ	SKCM	TCGA	SRSNLTSLL	DEG_APCC_DBOX_1	0.1944
p.E365K	DO51246	SKCM	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.1944
p.V379M	TCGA-GN-A264	SKCM	TCGA	SRSNLTSLL	DEG_APCC_DBOX_1	0.3056
p.V379M	DO37527	SKCM	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.3056
p.R371Q	TCGA-GN-A266	SKCM	TCGA	SRSNLTSLL	DEG_APCC_DBOX_1	0.7329
p.R371Q	DO229462	SKCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.7329
p.R371Q	DO37432	SKCM	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.7329
p.P385S	DO229010	COCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.1389
p.P385S	DO229013	COCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.1389
p.P385S	DO229016	COCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.1389
p.P385S	DO229003	COCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.1389
p.P385S	DO229005	COCA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.1389
p.P381S	DO234215	ESAD	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.25
p.T375I	DO233918	GACA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.5966
p.S362G	DO228253	MALY	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.1111
p.P385L	DO222702	MELA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.1389
p.Y360C	DO222837	MELA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.0556
p.P381A	DO231284	PACA	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.25
p.S376Y	DO51171	PAEN	ICGC	SRSNLTSLL	DEG_APCC_DBOX_1	0.6009
p.P381L	SIDM00003	Melanoma	GDSC	SRSNLTSLL	DEG_APCC_DBOX_1	0.25
p.P381L	ACH-002159	Skin Cancer	CCLE	SRSNLTSLL	DEG_APCC_DBOX_1	0.25
p.P381L	M14	skin	COSMIC	SRSNLTSLL	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q58DX5	Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2	DEG_APCC_DBOX_1	370:378	SRSNLTSLL	APC,CDC20,FZR1	0.7554	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons