DegronMD - Q5BJF6(ODF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H87Y	TCGA-55-6642	LUAD	TCGA	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.2778
p.K102N	DO51640	CESC	ICGC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.1667
p.A79T	DO233259	GACA	ICGC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.0556
p.A79T	DO36531	READ	ICGC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.0556
p.A79T	DO42528	UCEC	ICGC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.0556
p.D89G	DO44431	HNSC	ICGC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation altering degron motif	0.7198
p.E87K	DO229056	LICA	ICGC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.2778
p.M96V	DO50811	LIRI	ICGC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation altering degron motif	0.7208
p.T85M	DO228176	PBCA	ICGC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.2222
p.T85M	NCI-H1623	lung	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.2222
p.P80H	DO38707	STAD	ICGC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.0833
p.T92M	SIDM01015	Chronic Myelogenous Leukemia	GDSC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation altering degron motif	0.8534
p.T92M	SIDM00179	Melanoma	GDSC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation altering degron motif	0.8534
p.T92M	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation altering degron motif	0.8534
p.T92M	MZ2-MEL	skin	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation altering degron motif	0.8534
p.I91T	SIDM00150	Colorectal Carcinoma	GDSC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation altering degron motif	0.5966
p.I91T	KM12	large intestine	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation altering degron motif	0.5966
p.I86T	ACH-000969	Colon/Colorectal Cancer	CCLE	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.25
p.I86T	KM12	large intestine	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.25
p.V97M	ACH-001982	Metastasis	CCLE	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.3056
p.T87M	MZ2-MEL	skin	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.2778
p.T87M	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.2778
p.E103K	GEO	large intestine	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.1389
p.M105L	MRK-nu-1	breast	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	89:96	Mutation rewiring degron network	0.0833

Kaplan plot for ODF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ODF2

UniProt ID: Q5BJF6

Entrez ID: 4957

Protein name: Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ODF2 in