DegronMD

Uniprot ID: Q5BJF6

Source protein: Outer dense fiber protein 2

Source gene: ODF2

Class: DEG_SCF_FBW7_1

Location: 89:96

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 86.15

COIL: 0.8384

CONS_SCORE: 0.7822

DSS_SCORE: 0.4759

HELIX: 0.0581

FCONS_SCORE: 1.0445

RIG_SCORE: 0.7214

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H87Y	TCGA-55-6642	LUAD	TCGA	LEITPPSS	DEG_SCF_FBW7_1	0.2778
p.K102N	DO51640	CESC	ICGC	LEITPPSS	DEG_SCF_FBW7_1	0.1667
p.A79T	DO233259	GACA	ICGC	LEITPPSS	DEG_SCF_FBW7_1	0.0556
p.A79T	DO36531	READ	ICGC	LEITPPSS	DEG_SCF_FBW7_1	0.0556
p.A79T	DO42528	UCEC	ICGC	LEITPPSS	DEG_SCF_FBW7_1	0.0556
p.D89G	DO44431	HNSC	ICGC	LEITPPSS	DEG_SCF_FBW7_1	0.7198
p.E87K	DO229056	LICA	ICGC	LEITPPSS	DEG_SCF_FBW7_1	0.2778
p.M96V	DO50811	LIRI	ICGC	LEITPPSS	DEG_SCF_FBW7_1	0.7208
p.T85M	DO228176	PBCA	ICGC	LEITPPSS	DEG_SCF_FBW7_1	0.2222
p.T85M	NCI-H1623	lung	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	0.2222
p.P80H	DO38707	STAD	ICGC	LEITPPSS	DEG_SCF_FBW7_1	0.0833
p.T92M	SIDM01015	Chronic Myelogenous Leukemia	GDSC	LEITPPSS	DEG_SCF_FBW7_1	0.8534
p.T92M	SIDM00179	Melanoma	GDSC	LEITPPSS	DEG_SCF_FBW7_1	0.8534
p.T92M	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	0.8534
p.T92M	MZ2-MEL	skin	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	0.8534
p.I91T	SIDM00150	Colorectal Carcinoma	GDSC	LEITPPSS	DEG_SCF_FBW7_1	0.5966
p.I91T	KM12	large_intestine	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	0.5966
p.I86T	ACH-000969	Colon/Colorectal Cancer	CCLE	LEITPPSS	DEG_SCF_FBW7_1	0.25
p.I86T	KM12	large_intestine	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	0.25
p.V97M	ACH-001982	Metastasis	CCLE	LEITPPSS	DEG_SCF_FBW7_1	0.3056
p.T87M	MZ2-MEL	skin	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	0.2778
p.T87M	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	0.2778
p.E103K	GEO	large_intestine	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	0.1389
p.M105L	MRK-nu-1	breast	COSMIC	LEITPPSS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5BJF6	Outer dense fiber protein 2	DEG_SCF_FBW7_1	89:96	LEITPPSS	FBXW7	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons