DegronMD - Q5C9Z4(NOM1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K227E	TCGA-BR-7851	STAD	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation substituting flanking lysine	0.25
p.K227E	TCGA-K4-A3WS	BLCA	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation substituting flanking lysine	0.25
p.K227E	DO480	BLCA	ICGC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation substituting flanking lysine	0.25
p.K227E	DO38711	STAD	ICGC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation substituting flanking lysine	0.25
p.D214G	TCGA-BS-A0UF	UCEC	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.6087
p.D214G	DO41488	UCEC	ICGC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.6087
p.S210G	TCGA-HF-7132	STAD	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2778
p.S210G	DO38214	STAD	ICGC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2778
p.D217H	TCGA-MP-A4TK	LUAD	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.6577
p.D217H	DO45384	LUAD	ICGC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.6577
p.R213L	TCGA-OR-A5KB	ACC	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.8428
p.A222P	TCGA-W5-AA2X	CHOL	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2778
p.S225F	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1944
p.S225F	ACH-000841	Lung Cancer	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1944
p.S225F	NCI-H2087	lung	COSMIC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1944
p.S206C	SIDM00963	Breast Carcinoma	GDSC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1667
p.S206C	ACH-000927	Breast Cancer	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1667
p.S206C	BT-474	breast	COSMIC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1667
p.R213H	SIDM01609	Endometrial Carcinoma	GDSC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.8244
p.R213H	ACH-000972	Endometrial/Uterine Cancer	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.8244
p.V207A	SIDM00228	Thyroid Gland Carcinoma	GDSC	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1944
p.V207A	ACH-000897	Thyroid Cancer	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1944
p.P208S	ACH-001028	Rhabdoid	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2222
p.A222T	ACH-001119	Lymphoma	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2778

Kaplan plot for NOM1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOM1

UniProt ID: Q5C9Z4

Entrez ID: 64434

Protein name: Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NOM1 in