DegronMD

Uniprot ID: Q5C9Z4

Source protein: Nucleolar MIF4G domain-containing protein 1

Source gene: NOM1

Class: DEG_APCC_DBOX_1

Location: 212:220

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9834

ASA_SCORE: 62.0111

COIL: 0.4676

CONS_SCORE: 0.4164

DSS_SCORE: 0.2791

HELIX: 0.4977

FCONS_SCORE: 1.5341

RIG_SCORE: 0.8103

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K227E	TCGA-BR-7851	STAD	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	0.25
p.K227E	TCGA-K4-A3WS	BLCA	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	0.25
p.K227E	DO480	BLCA	ICGC	ARDGLDYIL	DEG_APCC_DBOX_1	0.25
p.K227E	DO38711	STAD	ICGC	ARDGLDYIL	DEG_APCC_DBOX_1	0.25
p.D214G	TCGA-BS-A0UF	UCEC	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	0.6087
p.D214G	DO41488	UCEC	ICGC	ARDGLDYIL	DEG_APCC_DBOX_1	0.6087
p.S210G	TCGA-HF-7132	STAD	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	0.2778
p.S210G	DO38214	STAD	ICGC	ARDGLDYIL	DEG_APCC_DBOX_1	0.2778
p.D217H	TCGA-MP-A4TK	LUAD	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	0.6577
p.D217H	DO45384	LUAD	ICGC	ARDGLDYIL	DEG_APCC_DBOX_1	0.6577
p.R213L	TCGA-OR-A5KB	ACC	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	0.8428
p.A222P	TCGA-W5-AA2X	CHOL	TCGA	ARDGLDYIL	DEG_APCC_DBOX_1	0.2778
p.S225F	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	ARDGLDYIL	DEG_APCC_DBOX_1	0.1944
p.S225F	ACH-000841	Lung Cancer	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	0.1944
p.S225F	NCI-H2087	lung	COSMIC	ARDGLDYIL	DEG_APCC_DBOX_1	0.1944
p.S206C	SIDM00963	Breast Carcinoma	GDSC	ARDGLDYIL	DEG_APCC_DBOX_1	0.1667
p.S206C	ACH-000927	Breast Cancer	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	0.1667
p.S206C	BT-474	breast	COSMIC	ARDGLDYIL	DEG_APCC_DBOX_1	0.1667
p.R213H	SIDM01609	Endometrial Carcinoma	GDSC	ARDGLDYIL	DEG_APCC_DBOX_1	0.8244
p.R213H	ACH-000972	Endometrial/Uterine Cancer	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	0.8244
p.V207A	SIDM00228	Thyroid Gland Carcinoma	GDSC	ARDGLDYIL	DEG_APCC_DBOX_1	0.1944
p.V207A	ACH-000897	Thyroid Cancer	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	0.1944
p.P208S	ACH-001028	Rhabdoid	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	0.2222
p.A222T	ACH-001119	Lymphoma	CCLE	ARDGLDYIL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5C9Z4	Nucleolar MIF4G domain-containing protein 1	DEG_APCC_DBOX_1	212:220	ARDGLDYIL	APC,CDC20,FZR1	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARDGLDYIL

Degron related mutations and impact score

Drug responses associated with NOM1 mutations

All proteins holding degron of ARDGLDYIL