DegronMD - Q5D862(FLG2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F1205Y	TCGA-13-1489	OV	TCGA	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.2778
p.F1205Y	DO28001	OV	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.2778
p.Q1194K	TCGA-55-6985	LUAD	TCGA	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.2222
p.Q1194K	DO25659	LUAD	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.2222
p.H1195Q	TCGA-78-8662	LUAD	TCGA	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.25
p.H1195Q	DO45346	LUAD	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.25
p.F1189L	TCGA-AX-A0J0	UCEC	TCGA	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.0833
p.F1189L	TCGA-D1-A17Q	UCEC	TCGA	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.0833
p.F1189L	DO44890	LIHC	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.0833
p.F1189L	DO41903	UCEC	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.0833
p.F1189L	DO41133	UCEC	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.0833
p.S1191R	TCGA-BH-A1FN	BRCA	TCGA	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.1389
p.S1191R	DO5214	BRCA	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.1389
p.G1213C	TCGA-CG-5721	STAD	TCGA	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.0556
p.G1213C	DO38192	STAD	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.0556
p.S1192C	TCGA-CV-A6K2	HNSC	TCGA	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.1667
p.S1192C	DO52079	HNSC	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.1667
p.S1191N	DO33248	PACA	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.1389
p.T1203A	DO36221	PRAD	ICGC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation altering degron motif	0.7139
p.Q1201P	SIDM00241	Breast Carcinoma	GDSC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation altering degron motif	0.5924
p.Q1201P	ACH-002179	Breast Cancer	CCLE	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation altering degron motif	0.5924
p.Q1201P	OCUB-M	breast	COSMIC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation altering degron motif	0.5924
p.I1196V	SIDM00534	Colorectal Carcinoma	GDSC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.2778
p.I1196V	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.2778
p.I1196V	HT-115	large intestine	COSMIC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation rewiring degron network	0.2778
p.Q1201K	ACH-001591	Lung Cancer	CCLE	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation altering degron motif	0.5833
p.Q1201K	NCI-H1417	lung	COSMIC	DSGQST	DEG_SCF_TRCP1_1	1198:1203	Mutation altering degron motif	0.5833

Kaplan plot for FLG2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FLG2

UniProt ID: Q5D862

Entrez ID: 388698

Protein name: Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FLG2 in