DegronMD

Uniprot ID: Q5D862

Source protein: Filaggrin-2

Source gene: FLG2

Class: DEG_SCF_TRCP1_1

Location: 1198:1203

E3 ligase: BTRC

DEGRON score: 0.9084

ASA_SCORE: 93.5167

COIL: 0.9307

CONS_SCORE: 0.3551

DSS_SCORE: 0.6544

HELIX: 0.0392

FCONS_SCORE: 0.823

RIG_SCORE: 0.5904

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1205Y	TCGA-13-1489	OV	TCGA	DSGQST	DEG_SCF_TRCP1_1	0.2778
p.F1205Y	DO28001	OV	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.2778
p.Q1194K	TCGA-55-6985	LUAD	TCGA	DSGQST	DEG_SCF_TRCP1_1	0.2222
p.Q1194K	DO25659	LUAD	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.2222
p.H1195Q	TCGA-78-8662	LUAD	TCGA	DSGQST	DEG_SCF_TRCP1_1	0.25
p.H1195Q	DO45346	LUAD	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.25
p.F1189L	TCGA-AX-A0J0	UCEC	TCGA	DSGQST	DEG_SCF_TRCP1_1	0.0833
p.F1189L	TCGA-D1-A17Q	UCEC	TCGA	DSGQST	DEG_SCF_TRCP1_1	0.0833
p.F1189L	DO44890	LIHC	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.0833
p.F1189L	DO41903	UCEC	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.0833
p.F1189L	DO41133	UCEC	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.0833
p.S1191R	TCGA-BH-A1FN	BRCA	TCGA	DSGQST	DEG_SCF_TRCP1_1	0.1389
p.S1191R	DO5214	BRCA	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.1389
p.G1213C	TCGA-CG-5721	STAD	TCGA	DSGQST	DEG_SCF_TRCP1_1	0.0556
p.G1213C	DO38192	STAD	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.0556
p.S1192C	TCGA-CV-A6K2	HNSC	TCGA	DSGQST	DEG_SCF_TRCP1_1	0.1667
p.S1192C	DO52079	HNSC	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.1667
p.S1191N	DO33248	PACA	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.1389
p.T1203A	DO36221	PRAD	ICGC	DSGQST	DEG_SCF_TRCP1_1	0.7139
p.Q1201P	SIDM00241	Breast Carcinoma	GDSC	DSGQST	DEG_SCF_TRCP1_1	0.5924
p.Q1201P	ACH-002179	Breast Cancer	CCLE	DSGQST	DEG_SCF_TRCP1_1	0.5924
p.Q1201P	OCUB-M	breast	COSMIC	DSGQST	DEG_SCF_TRCP1_1	0.5924
p.I1196V	SIDM00534	Colorectal Carcinoma	GDSC	DSGQST	DEG_SCF_TRCP1_1	0.2778
p.I1196V	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGQST	DEG_SCF_TRCP1_1	0.2778
p.I1196V	HT-115	large_intestine	COSMIC	DSGQST	DEG_SCF_TRCP1_1	0.2778
p.Q1201K	ACH-001591	Lung Cancer	CCLE	DSGQST	DEG_SCF_TRCP1_1	0.5833
p.Q1201K	NCI-H1417	lung	COSMIC	DSGQST	DEG_SCF_TRCP1_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5D862	Filaggrin-2	DEG_SCF_TRCP1_1	1198:1203	DSGQST	BTRC	0.9084	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGQST

Degron related mutations and impact score

Drug responses associated with FLG2 mutations

All proteins holding degron of DSGQST