DegronMD - Q5FYA8(ARSH)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R518H	TCGA-2W-A8YY	CESC	TCGA	HRRTLTPVP	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.8244
p.R518H	TCGA-B5-A3FC	UCEC	TCGA	HRRTLTPVP	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.8244
p.R518H	DO223732	CESC	ICGC	HRRTLTPVP	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.8244
p.R518H	DO41871	UCEC	ICGC	HRRTLTPVP	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.8244
p.P525T	TCGA-34-5234	LUSC	TCGA	HRRTLTPVP	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.5919
p.P525T	DO26810	LUSC	ICGC	HRRTLTPVP	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.5919
p.R519M	TCGA-EO-A22R	UCEC	TCGA	HRRTLTPVP	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.7521
p.R519M	DO42713	UCEC	ICGC	HRRTLTPVP	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.7521
p.A512T	SIDM00217	Colorectal Carcinoma	GDSC	HRRTLTPVP	DEG_APCC_DBOX_1	517:525	Mutation rewiring degron network	0.1944
p.A512T	SNU-1040	large intestine	COSMIC	HRRTLTPVP	DEG_APCC_DBOX_1	517:525	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons