DegronMD

Uniprot ID: Q5FYA8

Source protein: Arylsulfatase H

Source gene: ARSH

Class: DEG_APCC_DBOX_1

Location: 517:525

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7617

ASA_SCORE: 77.3111

COIL: 0.708

CONS_SCORE: 0.3173

DSS_SCORE: 0.2962

HELIX: 0.2733

FCONS_SCORE: 1.1292

RIG_SCORE: 0.8052

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R518H	TCGA-2W-A8YY	CESC	TCGA	HRRTLTPVP	DEG_APCC_DBOX_1	0.8244
p.R518H	TCGA-B5-A3FC	UCEC	TCGA	HRRTLTPVP	DEG_APCC_DBOX_1	0.8244
p.R518H	DO223732	CESC	ICGC	HRRTLTPVP	DEG_APCC_DBOX_1	0.8244
p.R518H	DO41871	UCEC	ICGC	HRRTLTPVP	DEG_APCC_DBOX_1	0.8244
p.P525T	TCGA-34-5234	LUSC	TCGA	HRRTLTPVP	DEG_APCC_DBOX_1	0.5919
p.P525T	DO26810	LUSC	ICGC	HRRTLTPVP	DEG_APCC_DBOX_1	0.5919
p.R519M	TCGA-EO-A22R	UCEC	TCGA	HRRTLTPVP	DEG_APCC_DBOX_1	0.7521
p.R519M	DO42713	UCEC	ICGC	HRRTLTPVP	DEG_APCC_DBOX_1	0.7521
p.A512T	SIDM00217	Colorectal Carcinoma	GDSC	HRRTLTPVP	DEG_APCC_DBOX_1	0.1944
p.A512T	SNU-1040	large_intestine	COSMIC	HRRTLTPVP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5FYA8	Arylsulfatase H	DEG_APCC_DBOX_1	517:525	HRRTLTPVP	APC,CDC20,FZR1	0.7617	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons