DegronMD - Q5GAN4(RNASE12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I7V	TCGA-05-4395	LUAD	TCGA	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.25
p.I7V	DO25444	LUAD	ICGC	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.25
p.V10L	TCGA-55-8511	LUAD	TCGA	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.5654
p.V10L	DO24940	LUAD	ICGC	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.5654
p.E15K	TCGA-BK-A6W3	UCEC	TCGA	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.7022
p.E15K	DO50076	UCEC	ICGC	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.7022
p.D20N	TCGA-F5-6814	READ	TCGA	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.1944
p.D20N	DO36556	READ	ICGC	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.1944
p.L12P	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6471
p.L12P	ACH-000916	Lung Cancer	CCLE	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6471
p.L12P	NCI-H1573	lung	COSMIC	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6471
p.L9F	ACH-001794	Liposarcoma	CCLE	VLLFWE	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons