DegronMD

Uniprot ID: Q5GAN4

Source protein: Probable inactive ribonuclease-like protein 12

Source gene: RNASE12

Class: LIG_APCC_ABBA_1

Location: 10:15

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9455

ASA_SCORE: 107.8167

COIL: 0.6593

CONS_SCORE: 0.5622

DSS_SCORE: 0.0004

HELIX: 0.2005

FCONS_SCORE: 1.3676

RIG_SCORE: 1.0284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I7V	TCGA-05-4395	LUAD	TCGA	VLLFWE	LIG_APCC_ABBA_1	0.25
p.I7V	DO25444	LUAD	ICGC	VLLFWE	LIG_APCC_ABBA_1	0.25
p.V10L	TCGA-55-8511	LUAD	TCGA	VLLFWE	LIG_APCC_ABBA_1	0.5654
p.V10L	DO24940	LUAD	ICGC	VLLFWE	LIG_APCC_ABBA_1	0.5654
p.E15K	TCGA-BK-A6W3	UCEC	TCGA	VLLFWE	LIG_APCC_ABBA_1	0.7022
p.E15K	DO50076	UCEC	ICGC	VLLFWE	LIG_APCC_ABBA_1	0.7022
p.D20N	TCGA-F5-6814	READ	TCGA	VLLFWE	LIG_APCC_ABBA_1	0.1944
p.D20N	DO36556	READ	ICGC	VLLFWE	LIG_APCC_ABBA_1	0.1944
p.L12P	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VLLFWE	LIG_APCC_ABBA_1	0.6471
p.L12P	ACH-000916	Lung Cancer	CCLE	VLLFWE	LIG_APCC_ABBA_1	0.6471
p.L12P	NCI-H1573	lung	COSMIC	VLLFWE	LIG_APCC_ABBA_1	0.6471
p.L9F	ACH-001794	Liposarcoma	CCLE	VLLFWE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5GAN4	Probable inactive ribonuclease-like protein 12	LIG_APCC_ABBA_1	10:15	VLLFWE	APC,CDC20,FZR1	0.9455	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons