DegronMD - Q5GFL6(VWA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D505Y	TCGA-AP-A1DV	UCEC	TCGA	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.25
p.D505Y	DO43186	UCEC	ICGC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.25
p.P503L	TCGA-EB-A5UM	SKCM	TCGA	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.P503L	DO47282	SKCM	ICGC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.E489K	TCGA-EE-A29S	SKCM	TCGA	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1111
p.E489K	TCGA-EE-A3J5	SKCM	TCGA	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1111
p.E489K	DO47331	SKCM	ICGC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1111
p.E489K	DO37936	SKCM	ICGC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1111
p.P503T	DO234231	ESAD	ICGC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.P511R	DO233213	GACA	ICGC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.H496Y	SIDM00969	Ovarian Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.H496Y	SIDM00633	Breast Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.H496Y	SIDM00971	Breast Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.H496Y	SIDM00849	Kidney Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.H496Y	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.H496Y	SIDM00844	Burkitt's Lymphoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.H496Y	SIDM00721	Small Cell Lung Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.Q504P	SIDM01051	Ovarian Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2778
p.Q504P	ACH-000936	Ovarian Cancer	CCLE	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2778
p.Q504P	EFO-27	ovary	COSMIC	VMVYSD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2778

Kaplan plot for VWA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VWA2

UniProt ID: Q5GFL6

Entrez ID: 340706

Protein name: von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin and collagen) (AMACO) (Colon cancer secreted protein 2) (CCSP-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VWA2 in