DegronMD

Uniprot ID: Q5GFL6

Source protein: von Willebrand factor A domain-containing protein 2

Source gene: VWA2

Class: LIG_APCC_ABBA_1

Location: 497:502

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.688

ASA_SCORE: 38.0833

COIL: 0.4183

CONS_SCORE: 0.5173

DSS_SCORE: 0.3894

HELIX: 0.014

FCONS_SCORE: 0.8835

RIG_SCORE: 0.7927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D505Y	TCGA-AP-A1DV	UCEC	TCGA	VMVYSD	LIG_APCC_ABBA_1	0.25
p.D505Y	DO43186	UCEC	ICGC	VMVYSD	LIG_APCC_ABBA_1	0.25
p.P503L	TCGA-EB-A5UM	SKCM	TCGA	VMVYSD	LIG_APCC_ABBA_1	0.3056
p.P503L	DO47282	SKCM	ICGC	VMVYSD	LIG_APCC_ABBA_1	0.3056
p.E489K	TCGA-EE-A29S	SKCM	TCGA	VMVYSD	LIG_APCC_ABBA_1	0.1111
p.E489K	TCGA-EE-A3J5	SKCM	TCGA	VMVYSD	LIG_APCC_ABBA_1	0.1111
p.E489K	DO47331	SKCM	ICGC	VMVYSD	LIG_APCC_ABBA_1	0.1111
p.E489K	DO37936	SKCM	ICGC	VMVYSD	LIG_APCC_ABBA_1	0.1111
p.P503T	DO234231	ESAD	ICGC	VMVYSD	LIG_APCC_ABBA_1	0.3056
p.P511R	DO233213	GACA	ICGC	VMVYSD	LIG_APCC_ABBA_1	0.0833
p.H496Y	SIDM00969	Ovarian Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	0.3056
p.H496Y	SIDM00633	Breast Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	0.3056
p.H496Y	SIDM00971	Breast Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	0.3056
p.H496Y	SIDM00849	Kidney Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	0.3056
p.H496Y	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	0.3056
p.H496Y	SIDM00844	Burkitt's Lymphoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	0.3056
p.H496Y	SIDM00721	Small Cell Lung Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	0.3056
p.Q504P	SIDM01051	Ovarian Carcinoma	GDSC	VMVYSD	LIG_APCC_ABBA_1	0.2778
p.Q504P	ACH-000936	Ovarian Cancer	CCLE	VMVYSD	LIG_APCC_ABBA_1	0.2778
p.Q504P	EFO-27	ovary	COSMIC	VMVYSD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5GFL6	von Willebrand factor A domain-containing protein 2	LIG_APCC_ABBA_1	497:502	VMVYSD	APC,CDC20,FZR1	0.688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons