DegronMD - Q5H9K5(ZMAT1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P347T	TCGA-09-2044	OV	TCGA	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation altering degron motif	0.5919
p.P347T	DO28923	OV	ICGC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation altering degron motif	0.5919
p.E353G	TCGA-A6-5665	COAD	TCGA	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.2222
p.E353G	DO9756	COAD	ICGC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.2222
p.H358Y	TCGA-AA-3672	COAD	TCGA	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.0833
p.H358Y	DO9010	COAD	ICGC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.0833
p.G346R	TCGA-YD-A89C	SKCM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation altering degron motif	0.7568
p.G346R	DO219501	SKCM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation altering degron motif	0.7568
p.D335Y	SIDM00994	T-Lymphoblastic Leukemia	GDSC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.0833
p.D335Y	ACH-000105	Leukemia	CCLE	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.0833
p.D335Y	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.0833
p.S357L	SIDM00336	Melanoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.1111
p.S357L	ACH-000881	Skin Cancer	CCLE	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.1111
p.S357L	MEL-JUSO	skin	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.1111
p.H337N	SIDM00231	Kidney Carcinoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.1389
p.H337N	SIDM00445	Esophageal Carcinoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.1389
p.H337N	ACH-002292	Esophageal Cancer	CCLE	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.1389
p.H337N	OACp4C	oesophagus	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.1389
p.H337N	NCC010	kidney	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.1389
p.M351I	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.2778
p.M351I	ACH-000824	Esophageal Cancer	CCLE	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.2778
p.M351I	KYSE-510	oesophagus	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation rewiring degron network	0.2778
p.S345F	ACH-002396	Bone Cancer	CCLE	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation altering degron motif	0.7982
p.S345F	Sarc9371	bone	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	344:349	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZMAT1

UniProt ID: Q5H9K5

Entrez ID: 84460

Protein name: Zinc finger matrin-type protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZMAT1 in